Joseph to banish Welsh demons
Wales, who travel to Twickenham, and England are the top two teams in the standings - and only remaining unbeaten sides.
Their last meeting came on the same ground where Wales fought back to secure a 28-25 victory, a success which ended up seeing them through the pool stages at England's expense.
Joseph was on the sidelines in that game, having picked up a chest injury, and revealed that it was difficult watching on helpless.
"It was tough one," he told England Rugby.
"The last ten minutes was horrible to watch and at the time I remember just thinking about trying to be fit for the week later. I can't remember the game too well, it wasn't a great time for any of us.
"It's a massive rivalry. Wales are always up for the game against us, so are we, it'll be a massive contest on Saturday and hopefully we'll have the backing of our home support to get the win.
"Each individual will look back and it'll hurt them massively, it will be a driving factor inside of everyone but we will prepare well and show what we are about on the pitch.
"We have built some momentum and hopefully we can keep building on what we've done already.
"The more we play together and train together, we are gelling nicely. The inter link between the forwards and the backs is working well and we are putting defences under pressure.
"We know what it feels like to not quite get there and obviously last Six Nations we didn't quite make it. The World Cup was not great for us so we have had our fair share of disappointment and everyone knows in their own mind that they don't want to feel like that again.
"So we are committed to doing all we can to win this next game and that's how we've approached it. Fingers crossed we can get that win."
Call-ups
Sources: @rbs_6_nations & @EnglandRugby