Concussed Bastareaud out of Ireland clash
The burly 28-year-old took a knock to the head while playing for Toulon against Lyon last Saturday.
He took a "neurological test" on Monday, which "does not allow him to be available for the Six Nations match against Ireland" said the French Federation in a statement.
Bastareaud was called up by Guy Noves for the first time in January having not been in the international set up since the 2015 World Cup, when Philippe Saint-Andre was the coach.
Bastareaud has played 39 times, scoring three tries, for France since making his debut against Wales in the Six Nations in 2009.
* Meanwhile Stade Francais back row forward Raphael Lakafia was called up to replace the injured Damien Chouly.
Chouly, 31 with 45 caps, had suffered a sprained ankle in training in Nice on Monday.
Lakafia, 28 with four caps, made his France debut against Ireland in 2011 in a World Cup warm-up.
Both Ireland and France won one and lost one of their opening two Six Nations games and a victory is vital to stay in the hunt to win this season's championship.
Agence France-Presse