Italy opt for new halfback pairing
Flyhalf Padovani, 22, comes in for his first start after two appearances off the bench in this year's competition and will line up alongside scrumhalf and Zebre teammate Palazzani this weekend.
The 24-year-old Palazzani has played 18 times for Italy, but started on just three occasions, however, Brunel is keen to mix things up after seeing his side lose their first three Six Nations matches.
Palazzani replaces the injured Edoardo Gori while Padovani takes the place of Kelly Haimona, who drops to the bench after a disappointing display in Italy's 36-20 defeat against Scotland last time out.
Brunel made two other changes to his starting XV, with injured lock Josh Furno (back) and hooker Leonardo Ghiraldini (shoulder) making way for George Biagi and Davide Giazzon.
"It will be a difficult match. Ireland are like us and still searching for their first win of the tournament, and they too must cope with numerous absentees," said Brunel, whose side are hoping to avoid the wooden spoon.
Date: Saturday, March 12
Venue: Aviva Stadium, Dublin
Kick-off: 13.30 (14.30 Italy time; 13.30 GMT)
Referee: Angus Gardner (Australia)
Assistant referees: Romain Poite (France), Marius van der Westhuizen (South Africa)
TMO: George Ayoub (Australia)
Agence France-Presse