Sharks name axed Springbok
Bosch recently made his Springbok debut against Argentina in Port Elizabeth during the Rugby Championship.
However, for the Springbok's match against Australia coach Allister Coetzee has opted to replace young Bosch with the experienced flyhalf Handré Pollard.
Bosch will slot into the flyhalf position for the Sharks this week, while Benhard Janse van Rensburg has been dropped from the matchday 23.
Aside from Bosch's inclusion, Du Preez has replaced Inny-Christian Radebe with utility back Garth April at fullback.
In the front row, there is only one change. Ross Geldenhuys returns from injury in place of John-Hubert Meyer at tight head prop.
Sharks: 15 Garth April, 14 Tythan Adams, 13 Jeremy Ward, 12 Lukhanyo Am, 11 Sibusiso Nkosi, 10 Curwin Bosch, 9 Louis Schreuder, 8 Lubabalo Mtembu, 7 Jacques Vermeulen, 6 Keegan Daniel, 5 Ruan Botha (captain), 4 Tyler Paul, 3 Ross Geldenhuys, 2 Armand van der Merwe, 1 Thomas du Toit.
Replacements: 16 Franco Marais, 17 Juan Schoeman, 18 Jean Droste, 19 Wian Vosloo, 20 Michael Claassens, 21 Marius Louw, 22 Rhyno Smith.
Date: Friday, September 8
Venue: Mbombela Stadium, Nelspruit
Kick-off: 17.15 (15.15 GMT)
Referee: Jaco van Heerden
Assistant Referees: Pieter Maritz, Stephan van Dyk
TMO: Johan Greeff