Steyn preferred to Plisson for Stade
The struggling French champions are underdogs for their trip to Leicester Tigers, who already pipped them into second place in the pool stages.
Another South African, Jono Ross, will start in the back row with Willem Alberts covering that position from the bench, meaning France international flank Antoine Burban misses out altogether.
Leicester have picked an all-Antipodean back-row with Australian flank Lachlan McCaffrey lining up alongside New Zealand pair Brendon O'Connor and Michael Fitzgerald.
Another Aussie, Peter Betham, starts at outside centre while Englishman Freddie Burns is prefered to Welshman Owen Williams at flyhalf.
Stade Français: 15 Djibril Camara, 14 Waisea Vuidarvuwalu, 13 Geoffrey Doumayrou, 12 Jonathan Danty, 11 Jérémy Sinzelle, 10 Morné Steyn, 9 Julien Dupuy, 8 Sergio Parisse (captain), 7 Raphaël Lakafia, 6 Jono Ross, 5 Alexandre Flanquart, 4 Hugh Pyle, 3 Rabah Slimani, 2 Remi Bonfils, 1 Zurabi Zhvania.
Replacements: 16 Craig Burden, 17 Dany Priso, 18 Paul Alo Emile, 19 Paul Gabrillagues, 20 Willem Alberts, 21 Julien Tomas, 22 Jules Plisson, 23 Hugo Bonneval.
Date: Sunday, April 11
Venue: Welford Road, Leicester
Kick-off: 13.45 (14.45 French time; 12.45 GMT)
Referee: Nigel Owens (Wales)
Assistant referees: George Clancy (Ireland), Leighton Hodges (Wales)
TMO: Derek Bevan (Wales)
Agence France-Presse