Front row duo back for Lions
Marx is back to full fitness after picking up a soft tissue neck injury in their 29-22 win over the Stormers in Round Eight.
Redelinghuys was also added to the injury list with a sprained wrist sustained in the same match.
The duo replaces replaces Armand van der Merwe and Pieter Scholtz respectively in the front row.
In the backline, Ross Cronjé gets the nod at scrumhalf with Francois de Klerk moving to the bench.
At centre Rohan Janse van Rensburg will partner Lionel Mapoe in midfield with Howard Mnisi also moving to the bench.
A new face among the reserves is new recruit Sylvian Mahuza who has been in action for the Golden Lions XV in the Currie Cup Qualifying round.
Lions: 15 Jaco van der Walt, 14 Ruan Combrinck, 13 Lionel Mapoe, 12 Rohan Janse van Rensburg, 11 Courtnall Skosan, 10 Elton Jantjies, 9 Ross Cronje, 8 Warren Whiteley (captain), 7 Warwick Tecklenburg, 6 Jaco Kriel, 5 Franco Mostert, 4 Andries Ferreira, 3 Julian Redelinghuys, 2 Malcolm Marx, 1 Dylan Smith.
Replacements: 16 Armand van der Merwe, 17 Corne Fourie, 18 Jacques van Rooyen, 19 Ruan Ackermann, 20 Cyle Brink, 21 Francois de Klerk, 22 Howard Mnisi, 23 Sylvian Mahuza.
Date: Saturday, May 14
Venue: Ellis Park, Johannesburg
Kick-off: 19.15 (17.15 GMT; 05.15 Sunday May 15, NZ time)
Referee: Jaco van Heerden (South Africa)
Assistant referees: Jaco Peyper (South Africa), Lesego Legoete (South Africa)
TMO: Shaun Veldsman (South Africa)